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DNA has to be an appropriate size before library construction with the xGen™ cfDNA & FFPE Library Prep MC v2 Kit.
For genomic DNA or DNA derived from formalin-fixed, paraffin-embedded (FFPE) samples, we recommend using Covaris shearing to attain average insert sizes of 150–300 base pairs.
As cell-free DNA (cfDNA) typically has an average size of 160 base pairs, no further fragmentation is required.