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Gapmer antisense oligonucleotides (ASOs) include modified bases at each end of the Antisense Oligo (such as 2’MOE or Affinity Plus modified bases) with an internal stretch of unmodified DNA bases. The terminal modified bases can help to enhance stability and increase binding affinity to the target. The internal unmodified DNA bases are necessary to enable RNase H to bind to and cleave the RNA target.